Australian Prime Minister Scott Morrison says he intends to make a Covid-19 vaccine as “mandatory as you can possibly make it” for all Australians once it becomes available.

It emerged today that the Morrison Government has confirmed a landmark agreement with drug giant AstraZeneca to manufacture one of the world’s most promising coronavirus vaccines currently being developed by Oxford University researchers, reports.

If it’s proved safe to use, Prime Minister Scott Morrison believes the agreement will ensure Australians will be among the first countries in the world to secure the jab, revealing this morning it could be available to Aussies as soon as early next year.

The UK Government has already ordered 100 million doses.

Asked whether the vaccine would be mandatory, Morrison told 3AW’s Neil Mitchell that it needed to get to about 95 per cent of the population.

“I would expect it to be as mandatory as you can possibly make it,” the Prime Minister said.

“There are always exemptions for any vaccine on medical grounds but that should be the only basis.

“I mean we’re talking about a pandemic that has destroyed you know, the global economy and taken the lives of hundreds of thousands all around the world and over 450 Australians here.

“We need the most extensive and comprehensive response to this to get Australia back to normal.”

However, in response to suggestions there would be community resistance to mandating it, Morrison said the government had not yet made a firm decision and this would be made once the medical issues about the vaccine were known.

Morrison said there “we’ll take that issue when it presents when clinical trials are finished and we have to understand what the medical issues potentially might be and that’s why we’ll take advice on its application but … you know, I’m certainly open to that suggestion but that is not a position that the government has taken”.

Mitchell pointed out that there would be campaigns from the anti-vaxxers but the Prime Minister seemed unfazed.

“I’m used to that, I was the minister that established ‘no jab, no play’,” he said, referring to a programme that sees government benefits withheld from parents who do not vaccinate their children. “My view on this is pretty clear and not for turning.”

During a later press conference, Australia’s acting chief medical officer Professor Paul Kelly said the vaccine would at first, be voluntary.

“Of course, the first will be a voluntary call for people and I’m sure there will be long queues – socially distanced, of course – for this vaccine,” Kelly said.

Scott Morrison said Australia needs the most extensive and comprehensive response to Covid to get back to normal. Photo / File
Scott Morrison said Australia needs the most extensive and comprehensive response to Covid to get back to normal. Photo / File

He said there would be strong campaigns to encourage people “and we’ve had experience before of linking vaccination with other programmes and all of those things will be looked at over time”.

While the ‘no jab, no play’ programme is aimed at getting children vaccinated, the Prime Minister was asked what the government would do when they were adults.

“We’re going to take this one step at a time,” Morrison said.

“I don’t think offering jelly beans is the way to do that as you do with kids but we’ll take those issues as they present and consider what steps are necessary at that time.”

He said the rollout of the programme would also depend on clinical advice that would identify any vulnerabilities in communities.

“The obvious priority is around health workers and people like that,” he said.

“What is important to understand with any of these vaccines is it does protect you, it does protect you but it also protects the community and, as is the case with any vaccine, there will be some individuals who, for precise medical reasons, can have issues with any vaccine,” Morrison said.

“They and their safety and their health depends on the vaccine’s take-up more broadly in the community. That’s how they get protected.

“And this is an important part of our vaccine strategy, not just on Covid-19, but more broadly. We’ll seek its most widespread application, as we do with all important vaccines.”

A vaccine holds the key to life returning to normal for millions of Australians and the hope that international travel can resume in the future after the nation’s borders were closed earlier this year.

While Morrison cautioned that more work needed to be done to prove the vaccine was safe to use, he said the government will fund the rollout of more than 25 million doses to cover every Australian for free as soon as the drug is available which could be next year.

“The Oxford vaccine is one of the most advanced and promising in the world, and under this deal we have secured early access for every Australian,” Morrison said.

“If this vaccine proves successful we will manufacture and supply vaccines straight away under our own steam and make it free for 25 million Australians.

“However there is no guarantee that this, or any other, vaccine will be successful, which is why we are continuing our discussions with many parties around the world while backing our own researchers at the same time to find a vaccine.

Senior Clinical Research Nurse Ajithkumar Sukumaran prepares the vaccine to administer to a volunteer, at a clinic in London this month. Photo / AP
Senior Clinical Research Nurse Ajithkumar Sukumaran prepares the vaccine to administer to a volunteer, at a clinic in London this month. Photo / AP

In a “Letter of Intent” with drug company AstraZeneca to supply the University of Oxford’s Covid-19 vaccine candidate to Australia, medical manufacturer Becton Dickinson has also been engaged for the supply of millions of needles and syringes.

The Letter of Intent covers vaccine development, production in Australia and distribution with a formal agreement including the price of the vaccine to taxpayers to follow.

However it will be provided to all Australians free of charge.

Morrison said he was also working to ensure early access to the vaccine was secured “for countries in our Pacific family, as well as regional partners in Southeast Asia.”

How the vaccine works

The Oxford University vaccine is made from a genetically engineered virus that causes the common cold in chimpanzees and is known as ChAdOx1 nCoV-19.

Scientists have altered the virus to make it mimic the coronavirus and ensure the immune system can learn how to attack it. It does not involve injecting Covid-19 but a virus that “looks like” the virus to trigger an immune response.

Recent trials involving 1077 people showed promising signs that it can trigger an immune response but further trials are underway.

“The preliminary data shows that it is safe and induces a strong antibody response in all vaccinated volunteers, suggesting that an effective vaccine could be within reach,” Oxford University’s Rebecca Ashfield said in July.

“This trial was the first time that the vaccine had been given to humans: 543 healthy adults aged 18-55 were vaccinated with a single dose of ChAdOx1 nCoV-19. A further 534 people were given a control vaccine that gives similar minor reactions, including injection site redness and mild pain.

“Volunteers are having their immune response (both antibodies and T cell levels) monitored for at least 12 months, and will also be observed to see whether or not they develop Covid-19.

Jess O'Hara a research technician handles a sample from a volunteer whilst testing antibodies to see if they bind to the virus, in the laboratory at Imperial College in London. Photo / AP
Jess O’Hara a research technician handles a sample from a volunteer whilst testing antibodies to see if they bind to the virus, in the laboratory at Imperial College in London. Photo / AP

“The preliminary data from the trial clearly demonstrates that the vaccine induces an antibody response within 28 days. This response is in a similar range to that in individuals who have recovered from Covid-19, providing encouragement that the vaccine will be able to protect the majority of people against infection.

During the trials, 10 volunteers were also given a second “booster” dose of the vaccine which increased the antibody response to even higher levels.

“Importantly, the vaccine demonstrates an acceptable safety profile, with no vaccine-induced severe adverse events – that is, no major side-effects,” Dr Ashfield said.

‘Booster shots’ may be required

Scientists working on the vaccine believe that one dose may not be enough to protect against Covid-19 infections.

“My personal prediction — based on decreases in antibody levels in individuals infected with other types of coronavirus, rather than data from the current vaccine trial — is that we’re likely to need yearly boosters, similar to annual flu jabs,” Dr Ashfield said.

Deliberately infecting people with the virus may be possible in future (after careful consideration of the ethical implications), but is not currently allowed.

A second trial has been launched involving 10,000 UK individuals, focusing on health workers and other trials are being conducted around the world, including in Brazil where rates of infection are high.

“The expanded UK trial will include children and older adults to estimate vaccine efficacy in these age groups. Immune responses in people over 70 are often lower than those in younger adults,” she said.